Effective Blood Pressure Control: Novel Medicine Shows Promising Efficacy in Hypertension Treatment
In an incredible breakthrough, a novel treatment named lorundrostat has promising results to tame stubborn high blood pressure cases, according to a significant global clinical trial. The Phase 3 Launch-HTN study confirms that this drug, an aldosterone synthase inhibitor, works safely and consistently in lowering blood pressure for a vast and diverse group of patients with resistant hypertension. That's awesome news since about 15% of high blood pressure cases involve dysregulation of aldosterone, a hormone that controls blood pressure.
Lorundrostat targets aldosterone production's root cause, inhibiting the enzyme responsible, CYP11B2. This approach leads to a reduction in blood pressure across diverse patient populations. In fact, it is the largest phase three trial to date for this class of treatment!
Manish Saxena, MD, Hypertension Specialist and lead researcher, informed us, "The Launch-HTN trial tested lorundostat in a large global patient base and discovered it to be safe while shrinking blood pressure consistently in all tested groups."
Lorundrostat works by inhibiting the adrenal glands from producing hormone aldosterone, thereby reducing blood pressure in the body. The drug reveals consistent and noteworthy reductions in systolic blood pressure for participants - a drop of 16.9 mmHg at Week 6 and 19 mmHg at Week 12!
Cheng-Han Chen, MD, and Rigved Tadwalkar, MD, FACC - two experts not involved in the study - also shared excitement with Medical News Today, viewing lorundrostat as a new weapon against difficult-to-treat hypertension cases.
As we continue to strive for better blood pressure control in our population, experts believe lorundrostat could offer hope to the many patients who have exhausted conventional treatment options.
[1] https://www.ncbi.nlm.nih.gov/pubmed/32868802[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860679/[3] https://www.ncbi.nlm.nih.gov/pubmed/31916215[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870375/[5] https://www.ncbi.nlm.nih.gov/pubmed/31593975
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